Clinical Evidence

Masimo is passionate about making innovative technologies that give clinicians the tools they need to do what is best for patient care. That's why it is gratifying to see so many independent clinicians and clinical researchers take the time to independently evaluate our products and technologies.

Click on the links below to read the featured studies from all of Masimo’s technologies, or in the sections below for access by subject area to all studies.*

Featured Clinical Studies

Masimo SET® Pulse Oximetry

Accuracy of Pulse Oximeters Intended for Hypoxemic Pediatric Patients.
Harris BU, Char DS, Feinstein JA, Verma A, Shiboski SC, Ramamoorthy C. Pediatr Crit Care Med. 2016 Apr;17(4):315-20.
Performance of Three New-Generation Pulse Oximeters during Motion and Low Perfusion in Volunteers.
Shah N., Ragaswamy H.B., Govindugari K., Estanol L. J Clin Anesth. 2012 May 22.
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Prevention of Retinopathy of Prematurity in Preterm Infants through Changes in Clinical Practice and SpO2 Technology.
Castillo A., Deulofeut R., Critz A., Sola A. Acta Paediatr. 2011 Feb;100(2):188-92.
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Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39,821 newborns.
de-Wahl Granelli A., Wennergren M., Sandberg K., Mellander M., Bejlum C., Inganäs L., Eriksson M., Segerdahl N., Agren A., Ekman-Joelsson B.M., Sunnegårdh J., Verdicchio M., Östman-Smith I. BMJ. 2009;Jan 8;338.
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More Reliable Oximetry Reduces the Frequency of Arterial Blood Gas Analyses and Hastens Oxygen Weaning after Cardiac Surgery: A Prospective, Randomized Trial of the Clinical Impact of a New Technology.
Durbin C.G. Jr., Rostow S.K. Crit Care Med. 2002 Aug;30(8):1735-40.
Reliability of Conventional and New Pulse Oximetry in Neonatal Patients.
Hay W.W., Rodden D.J., Collins S.M., Melara D.L., Hale K.A., Fashaw L.M. J Perinatol. 2002 Jul-Aug;22(5):360-6.
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"Motion-Resistant" Pulse Oximetry: A Comparison of New and Old Models.
Barker S.J. Anesth Analg. 2002 Oct;95(4):967-72.
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Patient SafetyNet

Impact of Pulse Oximetry Surveillance on Rescue Events and Intensive Care Unit Transfers: A Before-And-After Concurrence Study.
Taenzer A.H., Pyke J.B., McGrath S.P., Blike G.T. Anesthesiology. 2010 Feb;112(2):282-7.
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Postoperative Monitoring – The Dartmouth Experience.
Taenzer A.H., Blike, G. T. APSF Newsletter 2012.Available at: Accessed June 14, 2012.
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Total Hemoglobin (SpHb®)

Continuous and noninvasive hemoglobin monitoring reduces red blood cell transfusion during neurosurgery: a prospective cohort study.
Awada WN, Mohmoued MF, Radwan TM, Hussien GZ, Elkady HW. J Clin Monit Comput. 2015 Feb 4. [Epub ahead of print] PubMed PMID: 25649717.
Continuous Non-invasive Hemoglobin Monitoring during Orthopedic Surgery: A Randomized Trial
Ehrenfeld JM, Henneman JP, Bulka CM, Sandberg WS. 2014. J Blood Disorders Transf 5:237.doi:10.4172/2155-9864.1000237.
Trending and Accuracy of Noninvasive Hemoglobin Monitoring in Pediatric Perioperative Patients
Patino M, Schultz L, Hossain M, Moeller J, Mahmoud M, Gunter J, Kurth CD. Anesth Analg. 2014 Jul 17. [Epub ahead of print] PubMed PMID: 25036374.
Accuracy of a Continuous Noninvasive Hemoglobin Monitor in Intensive Care Unit Patients.
Frasca D., Dahyot-Fizelier C., Catherine K., Levrat Q., Debaene B., Mimoz O. Crit Care Med. 2011 Oct;39(10):2277-82.
The Accuracy of Noninvasive and Continuous Total Hemoglobin Measurement by Pulse CO-Oximetry in Human Subjects Undergoing Hemodilution.
Macknet M.R., Allard M., Applegate R.L., Rook J. Anesth Analg. 2010 Dec;111(6):1424–6.
Reduction in Red Blood Cell Transfusions during Neurosurgery with Noninvasive and Continuous Hemoglobin Monitoring
Awada WNFM et al. Anesth Analg 2013; (117 suppl): 50 (abstract).
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Pleth Variability Index (PVI®)

Standardization of Care: Impact of an Enhanced Recovery Protocol on Length of Stay, Complications, and Direct Costs after Colorectal Surgery
Thiele RH, Rea KM, Turrentine FE, Friel CM, Hassinger TE, Goudreau BJ, Umapathi BA, Kron IL, Sawyer RG, Hedrick TL. Journal of the American College of Surgeons (2015), doi: 10.1016/j.jamcollsurg.2014.12.042.
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Goal-Directed Fluid Management Based on the Pulse Oximeter-Derived Pleth Variability Index Reduces Lactate Levels and Improves Fluid Management.
Forget P, Lois F, de Kock M. Anesth Analg. 2010 Oct;111(4):910-4.
Pleth Variability Index to Monitor the Respiratory Variations in the Pulse Oximeter Plethysmographic Waveform Amplitude and Predict Fluid Responsiveness in the Operating Theatre.
Cannesson M., Desebbe O., Rosamel P., Delannoy B., Robin J., Bastien O., Lehot J.J. Br J Anaesth. 2008 Aug;101(2):200-6.
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Acoustic Respiration Rate (RRa®)

Accuracy of Respiratory Rate Monitoring using a Non-Invasive Acoustic Method after General Anaesthesia.
Mimoz O., Benard T., Gaucher A., Frasca D., Debaene B. Br J Anaesth. 2012 Feb 8.
Accuracy of Respiration Rate and Detection of Respiratory Pause by Acoustic Respiratory Monitoring in the PACU.
Ramsay M.A., Lagow E., Usman M. 65th Annual Post Graduate Assembly in Anesthesiology. December 9-11, 2011. Abs P-9137.
Monitoring Respiration in Upper GI Endoscopy Anesthesia.
Goudra B.G., Penugonda L. Proceedings of the 2011 Annual Meeting of the American Society of Anesthesiologists. A246.
Accuracy and Tolerance of a Novel Bioacoustic Respiratory Sensor in Pediatric Patients.
Macknet M.R., Kimball-Jones P.L., Applegate R.L., Martin R.D., Allard M.W. Anesthesiology. 2007; 107: A84.
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Carboxyhemoglobin (SpCO®)

Accuracy of Noninvasive Multiwave Pulse Oximetry Compared With Carboxyhemoglobin From Blood Gas Analysis in Unselected Emergency Department Patients.
Roth D., Herkner H., Schreiber W., Hubmann N., Gamper G., Laggner A.N., Havel C. Ann Emerg Med. 2011 Jul;58(1):74-9.
Noninvasive Pulse CO-Oximetry Expedites Evaluation and Management of Patients with Carbon Monoxide Poisoning.
Hampson N.B. Am J Emerg Med. 2012 May 23.
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Methemoglobin (SpMet®)

Severe Methemoglobinemia Detected by Pulse Oximetry.
Annabi E.H., Barker S,J. Anesth Analg. 2009;108:898–9.
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Oxygen Reserve Index (ORi)

The oxygen reserve index (ORi): a new tool to monitor oxygen therapy
Scheeren TWL, FJ Belda, A Perel. J Clin Monit Comput, 2017. DOI 10.1007/s10877-017-0049-4.
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The Relationship Between Oxygen Reserve Index and Arterial Partial Pressure of Oxygen During Surgery.
Applegate RL 2nd, Dorotta IL, Wells B, Juma D, Applegate PM. Anesth Analg. 2016 Mar 22. [Epub ahead of print] PubMed PMID: 27007078.
Oxygen Reserve Index A Novel Noninvasive Measure of Oxygen Reserve—A Pilot Study.
Szmuk P, Steiner JW, Olomu, PN, Ploski, RP, Sessler, DI, Ezri, T. Anesthesiology 2016; 124:00-00. doi:10.1097/ALN.0000000000001009
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Oxygen Reserve Index - a New, Noninvasive Method of Oxygen Reserve Measurement
Szmuk P, Steiner J., Olomu P., Dela Cruz J., Sessler D. American Society of Anesthesiologists 2014; BOC12.
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Regional Oximetry (O3)

Absolute and Trend Accuracy of a New Regional Oximeter in Healthy Volunteers During Controlled Hypoxia.
Redford D, Paidy S, Kashif F. Anesth Analg. 2014 Dec; 119(6):1315-1319. PubMed PMID: 25405692.
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SedLine® Brain Function Monitoring

Titration of Delivery and Recovery from Propofol, Alfentanil, and Nitrous Oxide Anesthesia.
Drover D.R., Lemmens H.J., Pierce E.T., Plourde G., Loyd G., Ornstein E., Prichep L.S., Chabot R.J., Gugino L. Anesthesiology 2002; 97:82–9.
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Masimo Capnography and Gas Monitoring

Evaluation of a Transportable Capnometer for Monitoring End-Tidal Carbon Dioxide.
Hildebrandt T., Espelund M., Olsen K.S. Anaesthesia. 2010 Oct;65(10):1017-21.
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* This section is intended to provide access to independent, objective, third-party, and government-sponsored clinical studies and abstracts conducted using Masimo noninvasive technologies, parameters, and products, which are known to Masimo's marketing department. We cannot guarantee that all clinical studies, abstracts, and research are represented. To view the individual clinical studies and abstracts, please click on the appropriate tab.

While clinical studies and abstracts support the effectiveness of Masimo noninvasive technologies and parameters, individual results may vary. Masimo cannot guarantee specific results achieved or suggested in individual studies. Always strictly follow the directions for use (DFU) found in the product manual. Use of Masimo technologies and parameters may not be appropriate for every individual or clinical condition. Understanding the indications and limitations of use can help you make the best decision for your individual situation.

Masimo devices with SpHb, SpCO, and/or SpMet monitoring are not intended to replace laboratory blood testing. Blood samples should be analyzed by laboratory instruments prior to clinical decision making.

ISA AX+ and ISA OR+ models and ORi parameter are not licensed for sale in Canada.